Escin Iia ( —— )

产品货号. M21790 CAS No. 158732-55-9

Escin IIa 是从七叶树（七叶树的种子）中分离出来的，对动物的急性炎症具有积极作用。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
10MG	￥2349	有现货
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

Escin Iia
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Escin IIa 是从七叶树（七叶树的种子）中分离出来的，对动物的急性炎症具有积极作用。
产品描述

Escin IIa, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats.
体外实验

——
体内实验

Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibits the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest.Escin IIa (10-50 mg/kg;p.o.;) potently inhibits ethanol-induced gastric mucosal lesions. Animal Model:Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats)Dosage:10-50 mg/kg Administration:p.o.Result:Showed a potent protective effect against ethanol-induced gastric lesions in rats.
同义词

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通路

Others
靶点

Other Targets
受体

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研究领域

——
适应症

——

化学信息

CAS Number

158732-55-9
分子量

1101.23
分子式

C??H??O??
纯度

>98% (HPLC)
溶解度

——
SMILES

OC[C@@]([C@H]([C@@H]1OC(/C(C)=C/C)=O)OC(C)=O)([C@@H](C[C@]23C)O)[C@](CC1(C)C)([H])C2=CC[C@@]4([H])[C@]3(CC[C@]([C@](C)5CO)([H])[C@@]4(CC[C@@H]5O[C@H](O[C@@H]6C(O)=O)[C@@H]([C@H]([C@@H]6O[C@@H]([C@@H]([C@H]7O)O)O[C@@H]([C@H]7O)CO)O)O[C@H](OC[C@H]8O)[C@@H]([C@H]8O)O)C)C
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Matsuda H, et al. Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals. Biol Pharm Bull. 1997;20(10):1092-1095. 2. Matsuda H, et al. Gastroprotections of escins Ia, Ib, IIa, and IIb on ethanol-induced gastric mucosal lesions in rats. Eur J Pharmacol. 1999;373(1):63-70.

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